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. 2014 Jun 29;18(3):R135. doi: 10.1186/cc13953

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Copyright © 2014 Poissy et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Kinetics of β-d-1,3-glucan, mannan and mannan antibody in five patients with candidaemia relapses. The dates of subsequent Candida isolations from blood are indicated by arrows. All patients, except Patient 4 with no detectable mannan, had values above the cutoff point for all tests, but with different kinetics. β-d-1,3-glucan (BDG) and mannan presented different kinetics of circulation in a single patient. The well-known transient nature of circulating mannan was observed and correlated with an inverse evolution of mannan antibody (Patients 1, 2, 3 and 5). Interestingly a sharp decrease in BDG was also observed over a short period of time (Patients 3, 4 and 5). cGLC/cBDG, concentration of BDG; cMn, concentration of mannan; Mn Ab, concentration of mannan antibody.