Figure 3.

Receiver operating characteristic curves for β-d-1,3-glucan (plain line) and mannan (dotted line) for the period from day 7 before to day 7 after the first positive blood culture. Area under the curve (95% confidence interval) for β-d-1,3-glucan (BDG) = 0.71 (0.61 to 0.81) with P < 0.0001; threshold for the best sensitivity/specificity ratio, 353 (0.65 to 0.74). Area under the curve (95% confidence interval) for mannan = 0.63 (0.52 to 0.74) with P = 0.009; threshold for the best sensitivity/specificity ratio, 0.2 (0.36 to 0.94). When considering how the two tests could complement each other, mannan has an important contribution to specificity for low BDG values while higher BDG values have improved sensitivity and specificity. cGLC, concentration of BDG; cMn, concentration of mannan.