Table 2.
Sensitivity, specificity and likelihood ratios for glucanaemia and mannanaemia
|
Sensitivity |
Specificity |
Positive LR |
Negative LR |
|||||
|---|---|---|---|---|---|---|---|---|
| Week -8/+8 | Day –7/+7 | Week -8/+8 | Day –7/+7 | Week -8/+8 | Day –7/+7 | Week -8/+8 | Day –7/+7 | |
| β-d-1,3-glucan |
100 |
97.1 |
30.6 |
30.6 |
1.4 |
1.4 |
0 |
0.1 |
| Mannan |
38.5 |
32.3 |
95.8 |
95.8 |
9.2 |
7.7 |
0.6 |
0.7 |
| Mannan antibody |
58.1 |
52.9 |
66.2 |
66.2 |
1.7 |
1.6 |
0.6 |
0.7 |
| Mannan or mannan antibody | 79.5 | 58.8 | 66.2 | 64.8 | 2.4 | 1.7 | 0.3 | 0.6 |
Sensitivity, specificity and positive and negative likelihood ratios (LRs) for glucanaemia (β-d-1,3-glucan), mannanaemia and anti-mannan antibody detection tests, as well as a combination of mannan/mannan antibody, during the whole period of serum collection (week 8 before to week 8 after the first positive blood culture (Week -8/+8)), and the critical period for diagnosis (day 7 before to day 7 after the first positive blood culture (Day –7/+7)).