Table 1.
Demographic and clinical characteristics a
| Clinical features | % ( n / N ) or mean ± SD |
|---|---|
| Patients |
2,137 |
| Main characteristics |
|
| Age at disease onset (yr) |
53 ± 14.8 |
| Follow-up duration (yr) |
12.5 ± 8.25 |
| Females (%) |
75.1 |
| Rheumatoid factor–positiveb |
68.3 (1,413/2,070) |
| Anti-CCP antibody–positive |
57.3 (1,024/1,785) |
| Shared epitope–positive |
62.6 (734/1,173) |
| Erosions |
54.4 (866/1,591) |
| Extraarticular manifestationsc |
31.3 (481/1,537) |
| Cardiovascular risk factors |
|
| Hypertension |
40.3 (846/2,100) |
| Diabetes mellitus |
13.1 (275/2,100) |
| Dyslipidemia |
38.3 (805/2,100) |
| Obesity |
19.6 (413/2,100) |
| Smoking habit |
27.4 (576/2,100) |
| Patients with cardiovascular events (total) |
18.2 (390/2,137) |
| Ischemic heart disease |
8.5 (181/2,137) |
| Heart failure |
5.7 (122/2,137) |
| Cerebrovascular accident |
5.6 (120/2,137) |
| Peripheral arteriopathy | 2.8 (60/2,137) |
aCCP: Cyclic citrullinated peptide; SD: Standard deviation. bAt least two determinations were required for analysis of this result. cExtraarticular manifestations of disease (if RA patients had at least one of the following manifestations: nodular disease: Felty’s syndrome, pulmonary fibrosis, rheumatoid vasculitis, secondary Sjögren’s syndrome) [4].