Table 2.
Factors associated with cardiovascular events in a series of 2,137 rheumatoid patients a
| Variables | HR (95% CI) | P -values | P -values b | |
|---|---|---|---|---|
| Males (reference: females) |
|
1.42 (1.07 to 1.87) |
0.015 |
|
| Age at RA diagnosis (by each year) |
|
1.07 (1.06 to 1.09) |
<0.001 |
|
| Hypertension |
|
1.40 (1.029 to 1.92) |
0.032 |
|
| Diabetes mellitus |
|
1.18 (0.83 to 1.68) |
0.344 |
|
| Obesity |
|
0.93 (0.67 to 1.31) |
0.702 |
|
| Dyslipidemia |
|
1.42 (1.05 to 1.93) |
0.022 |
|
| Smoking |
|
1.58 (1.26 to 1.99) |
<0.001 |
|
| rs2004640c |
TT |
1 (reference) |
– |
– |
| |
TG |
1.07 (0.79 to 1.45) |
0.664 |
0.670 |
| |
GG |
0.59 (0.38 to 0.92) |
0.020 |
0.034 |
| rs2070197c |
TT |
1 (reference) |
– |
– |
| |
TC |
1.16 (0.69 to 1.95) |
0.58 |
– |
| |
CC |
1.32 (0.32 to 5.52) |
0.39 |
– |
| rs10954213c |
AA |
1 (reference) |
– |
– |
| |
AG |
0.95 (0.71 to 1.26) |
0.73 |
0.738 |
| GG | 0.58 (0.36 to 0.95) | 0.03 | 0.049 |
aCI: Confidence interval; HR: Hazard ratio; RA: Rheumatoid arthritis. bP-values estimated on the basis of 10,000 replications. cAdjusted for sex, age at time of rheumatoid arthritis diagnosis and traditional cardiovascular disease risk factors (hypertension, diabetes mellitus, dyslipidemia, obesity, smoking habit).