Table 7.
Pro-inflammatory biomarker changes in Xuan Bai Cheng Qi and control groups before and after 10 - day treatment
|
Biomarkers |
XBCQ
a
(n = 22) |
Control
a
(n = 16) |
Treatment effect
d
(95% CI;
P-
value) |
||||
|---|---|---|---|---|---|---|---|
| Day 1 (Baseline) | Day 10 (End) | Mean D c | Day 1 (Baseline) | Day 10 (End) | Mean D | ||
| TNF - α (pg/mL) |
20.34 (4.90) |
4.92 (1.90) |
-15.42 (4.88) |
18.90 (3.61) |
6.47 (1.56) |
-12.43 (3.28)c |
-1.70 (-2.86, -0.54; .005) |
| IL - 2 (pg/mL) |
129.72 (18.27) |
53.50 (18.21) |
-76.23 (25.21) |
129.54 (28.70) |
84.10 (11.01) |
-45.43 (32.88)c |
-30.60 (-40.94, -20.25; < .001) |
| IL - 4 (pg/mL) |
5.98 (1.49) |
2.36 (0.56) |
-3.61 (1.78) |
6.15 (1.36) |
3.38 (1.25) |
-2.77 (1.70)c |
-1.02 (-1.65, -0.39; .002) |
| IL - 6 (pg/mL) |
3.95 (0.80) |
2.06 (0.53) |
-1.89 (0.95) |
3.81 (0.94) |
2.76 (0.67) |
-1.06 (0.48)c |
-0.74 (-1.20, -0.39; < .001) |
| IL - 8 (pg/mL) |
18.33 (3.93) |
9.09 (3.54) |
-9.24 (6.11) |
18.01 (4.17) |
14.92 (3.86) |
-3.08 (5.36)b |
-5.80 (-8.26, -3.34; < .001) |
| IL - 1β (pg/mL) | 13.42 (2.12) | 8.36 (1.02) | -7.89 (12.27) | 12.86 (1.98) | 9.23 (1.54) | -4.76 (8.97)c | -0.94 (-1.78, -0.10; .029) |
Abbreviations: CI confidence interval, IL - 1β interleukin - 1 beta, IL - 2 interleukin - 2, IL - 4 interleukin - 4, IL - 6 interleukin - 6, IL - 8 interleukin - 8, Mean D mean difference, TNF - α tumor necrosis factor alpha, XBCQ Xuan Bai Cheng Qi.
aData presented as mean (SD).
bP < .05.
cP < .01: change between pre - treatment and post - treatment (within group difference by paired t - test).
dCovariance analysis estimate with 95% confidence interval for difference.