Table 2.
Association of susceptibility loci identified in previous GWAS with ESCC risk in cases and controls
|
Susceptibility Loci |
Cases (n = 313) |
Controls (n = 314) |
P
values* |
Adjusted OR (95% CI)
†
|
||
|---|---|---|---|---|---|---|
| No. | % | No. | % | |||
|
rs738722
α
|
|
|
|
|
0.361 |
|
|
CC (Ref.) |
169 |
54.0 |
187 |
59.6 |
|
1.00 |
|
CT |
122 |
39.0 |
109 |
34.7 |
|
1.22 (0.87-1.73) |
|
TT |
22 |
7.0 |
18 |
5.7 |
|
1.34 (0.68-2.66) |
|
Trend test |
|
|
|
|
|
P = 0.242 |
|
TT + CT |
144 |
46.0 |
127 |
40.4 |
|
1.22 (0.88-1.69) |
|
rs2074356
β
|
|
|
|
|
0.011 |
|
|
CC (Ref.) |
196 |
62.6 |
227 |
72.3 |
|
1.00 |
|
TT |
2 |
0.6 |
5 |
1.6 |
|
0.61 (0.12-3.22) |
|
TC |
115 |
36.7 |
82 |
26.1 |
|
1.61 (1.12-2.30) |
|
Trend test |
|
|
|
|
|
P = 0.019 |
|
TT + TC |
117 |
37.3 |
87 |
27.7 |
|
1.52 (1.07-2.16) |
|
rs2274223
γ
|
|
|
|
|
0.006 |
|
|
AA (Ref.) |
172 |
55.0 |
209 |
66.6 |
|
1.00 |
|
AG |
122 |
39.0 |
96 |
30.6 |
|
1.70 (1.20-2.41) |
|
GG |
19 |
6.1 |
9 |
2.9 |
|
2.86 (1.22-6.71) |
|
Trend test |
|
|
|
|
|
P = 0.001 |
| GG + AG | 141 | 45.1 | 105 | 33.5 | 1.75 (1.25-2.46) | |
*Genotype distribution of rs738722, rs2074356 and rs2274223 was assessed by Chi-square test.
†ORs were adjusted for age, sex, smoking, drinking and HPV16 status.
αThe observed genotype frequencies of rs738722 among controls were in agreement with Hardy-Weinberg equilibrium (P = 0.689).
βThe observed genotype frequencies of rs2074356 among controls were in agreement with Hardy-Weinberg equilibrium (P = 0.433).
γThe observed genotype frequencies of rs2274223 among controls were in agreement with Hardy-Weinberg equilibrium (P = 0.609).