Table 4.
Joint effects and interactions of HPV16 L1 seropositivity and genotypes at susceptibility loci on the risk of esophageal squamous cell carcinoma in cases and controls
|
HPV16 status |
Susceptibility Loci |
Cases (n = 313) |
Controls (n = 314) |
Adjusted
P
values |
Adjusted OR (95% CI)
*
|
||
|---|---|---|---|---|---|---|---|
| No. | % | No. | % | ||||
| |
Rrs738722 |
|
|
|
|
|
|
|
Negative |
CC (Ref.) |
70 |
22.4 |
106 |
33.8 |
|
1.00 |
|
Negative |
TT + CT |
73 |
23.3 |
72 |
22.9 |
0.112 |
1.45 (0.92-2.30) |
|
Positive |
CC |
99 |
31.6 |
81 |
25.8 |
0.002 |
2.00 (1.29-3.10) |
|
Positive |
TT + CT |
71 |
22.7 |
55 |
17.5 |
0.003 |
2.09 (1.29-3.38) |
| |
G*HPV16 |
|
|
|
|
0.068 |
1.223 (0.99-1.52) |
| |
rsrs2074356 |
|
|
|
|
|
|
|
Negative |
CC (Ref.) |
87 |
27.8 |
128 |
40.8 |
|
1.00 |
|
Negative |
TT + TC |
56 |
17.9 |
50 |
15.9 |
0.054 |
1.61 (0.99-2.62) |
|
Positive |
CC |
109 |
33.9 |
99 |
31.5 |
0.005 |
1.78 (1.19-2.66) |
|
Positive |
TT + TC |
61 |
19.5 |
37 |
11.8 |
<0.001 |
2.66 (1.59-4.46) |
| |
G*HPV16 |
|
|
|
|
0.005 |
1.40 (1.11-1.77) |
| |
rsrs2274223 |
|
|
|
|
|
|
|
Negative |
AA (Ref.) |
82 |
26.2 |
118 |
37.6 |
|
1.00 |
|
Negative |
GG + AG |
61 |
19.5 |
60 |
19.1 |
0.055 |
1.59 (0.99-2.55) |
|
Positive |
AA |
90 |
28.8 |
91 |
29.0 |
0.042 |
1.55 (1.02-2.37) |
|
Positive |
GG + AG |
80 |
25.6 |
45 |
14.3 |
<0.001 |
3.17 (1.94-5.17) |
| GG*HPV16 | <0.001 | 1.53 (1.23-1.91) | |||||
*ORs were adjusted for age, sex, smoking and drinking in logistic regression models.
P values for gene*HPV16 interaction were calculated by conducting a 1-degree-of-freedom parameter (SNP*HPV16) as implemented in unconditional logistic regression with age, sex, smoking and drinking as covariates (22).