Table 2.
Linezolid pharmacokinetic parameters following intravenous administration of 600 mg twice daily in critically ill ICU patients
| Patient number | AUC 24 (mg*h/L) a | C min (mg/L) b |
|---|---|---|
| 1 |
99.1 |
0.67 |
| 2 |
50.1 |
<0.13c |
| 3 |
258.2 |
3.35 |
| 4 |
118.3 |
1.89 |
| 5 |
82.3 |
0.46 |
| 6 |
213.7 |
3.15 |
| 7 |
206.3 |
3.59 |
| 8 |
138.9 |
1.17 |
| 9 |
453.9 |
13.75 |
| 10 |
165.3 |
3.26 |
| 11 |
105.3 |
0.43 |
| 12 |
224.7 |
4.13 |
| 13 |
67.6 |
0.14 |
| 14 |
266.9 |
2.31 |
| 15 |
80.8 |
0.70 |
| 16 |
101.7 |
0.18 |
| 17 |
442.0 |
14.49 |
| 18 |
325.6 |
2.75 |
| 19 |
217.8 |
3.48 |
| 20 |
94.8 |
<0.13 |
| 21 |
122.0 |
1.03 |
| 22 |
144.6 |
3.70 |
| 23 |
141.8 |
2.22 |
| 24 |
250.8 |
8.18 |
| 25 |
157.1 |
1.45 |
| 26 |
50.8 |
<0.13 |
| 27 |
165.1 |
4.22 |
| 28 |
106.2 |
0.17 |
| 29 |
86.5 |
0.45 |
| 30 |
244.1 |
5.86 |
| Median |
143.3 |
2.06 |
| Range | 50.1 to 453.9 | <0.13 to 14.49 |
aAs determined by the NONMEM system, values from the start of the third administration of linezolid over 24 h; bas analyzed by liquid chromatography tandem mass spectrometry, values obtained directly before the fourth administration of linezolid if not indicated otherwise;
cvalue obtained directly before the fifth administration of linezolid. AUC24, concentration time curve over 24 h; Cmin, linezolid trough level.