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. 2014 Jul 5;11:57. doi: 10.1186/1742-4690-11-57

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Copyright © 2014 Jacobs et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Comparison with lymph node T cell responses of vaccinated macaques. Twelve genes were found to be differentially expressed in non-protected vs. protected macaques, and z-scores for these genes in macaques and Ag and Ag + Ant stimulated T cells were used to generate a heat map. A z-score was calculated for each gene and then mapped by gene and treatment. For the macaque data the z-scores for 10 CP macaques and 4 NP macaques were averaged and mapped for comparison to Ag and Ag + Ant treatments. The clustering dendrogram was generated based on a hierarchical clustering algorithm with completed linkage and Euclidian distance. CP = completely protected macaque, NP = non-protected macaque.