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Set7/9 differentially regulates E2F1-dependent genes in response to DNA damage. A model depicts the effect of Set7/9 on E2F1 activity. On the one hand, Set7/9 co-activates E2F1-dependent transcription of CCNE1 gene (left). On the other hand, Set7/9 represses E2F1-dependent transcription of Tp73 (right). In addition, Set7/9-mediated methylation of E2F1 on k185 results in de-stabilisation of the latter
