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Hypothetical model of Syn mechanisms of action. Wt intracellular Syn sequester actin monomer in a contest in which the severing protein cofilin 1 is active. Increased levels of extracellular Syn shift the balance of actin dynamics toward polymerization. This effect is achieved through the inactivation of cofilin 1 by phosphorylation, triggered by the clustering of GRP78 at the plasma membrane and activation of the depicted signaling pathway
