Table 1.
Frequency distributions of genotypes of pregnane X receptor (PXR) single nucleotide polymorphisms (SNPs) and their associations with the risk of lung cancer.
| Genotypes | Case n (%) | Control a n (%) | p Value b | Crude OR (95% CI) | Adjusted OR c (95% CI) |
|---|---|---|---|---|---|
| Discovery set | |||||
| Total no. of subjects | 1056 | 1056 | |||
| rs3814055C>T | |||||
| CC | 693 (65.6) | 706 (66.9) | 0.836 | 1.00 | 1.00 |
| TC | 328 (31.1) | 316 (29.9) | 1.06 (0.88–1.27) | 1.06 (0.88–1.28) | |
| TT | 35 (3.3) | 34 (3.2) | 1.05 (0.65–1.70) | 1.05 (0.65–1.70) | |
| rs3732360C>T | |||||
| CC | 347 (32.9) | 346 (32.8) | 0.758 | 1.00 | 1.00 |
| TC | 520 (49.2) | 533 (50.5) | 0.97 (0.80–1.18) | 0.97 (0.80–1.18) | |
| TT | 189 (17.9) | 177 (16.7) | 1.07 (0.83–1.37) | 1.07 (0.83–1.37) | |
| rs3814058C>T | |||||
| CC | 315 (29.8) | 365 (34.6) | 0.033 | 1.00 | 1.00 |
| TC | 505 (47.8) | 491 (46.5) | 1.19 (0.98–1.45) | 1.19 (0.98–1.45) | |
| TT | 236 (22.4) | 200 (18.9) | 1.37 (1.07–1.74) | 1.36 (1.07–1.73) | |
| TC + TT | 741 (70.2) | 691 (65.4) | 1.24 (1.04–1.49) | 1.24 (1.03–1.49) | |
| Validation set | |||||
| Total no. of subjects | 503 | 623 | |||
| rs3814058C>T | |||||
| CC | 122 (24.2) | 185 (29.7) | 0.093 | 1.00 | 1.00 |
| TC | 254 (50.5) | 303 (48.6) | 1.27 (0.96–1.68) | 1.28 (0.96–1.70) | |
| TT | 127 (25.3) | 135 (21.7) | 1.43 (1.02–1.99) | 1.47 (1.05–2.05) | |
| TC + TT | 381 (75.8) | 438 (70.3) | 1.32 (1.01–1.72) | 1.33 (1.02–1.75) | |
| Merged set | |||||
| Total no. of subjects | 1559 | 1679 | |||
| rs3814058C>T | |||||
| CC | 437 (28.0) | 550 (32.8) | 0.006 | 1.00 | 1.00 |
| TC | 759 (48.7) | 794 (47.2) | 1.20 (1.03–1.41) | 1.20 (1.02–1.41) | |
| TT | 363 (23.3) | 335 (20.0) | 1.36 (1.12–1.66) | 1.38 (1.13–1.67) | |
| Dominant model | |||||
| CC | 437 (28.0) | 550 (32.8) | 1.00 | 1.00 | |
| TC + TT | 1,122 (72.0) | 1,129 (67.2) | 1.25 (1.08–1.45) | 1.25 (1.08–1.45) | |
a The observed genotype frequencies were all in agreement with the Hardy-Weinberg equilibrium (p2 + 2pq + q2 = 1) in the control subjects of all sets (p > 0.05 for all); b p value from the chi-square test to assess the differences in frequency distributions of genotypes of PXR SNPs between cases and controls; c Adjusted in a logistic regression model that included age, sex, smoking status, alcohol use, and family history of cancer; and Bold numbers mean that the difference or association was statistically significant.