Table 2.
Stratification analysis of the PXR rs3814058C>T genotypes by selected variables in lung cancer patients and controls.
| Variables | Cases (n = 1559) | Controls (n = 1679) | Adjusted OR a (95% CI) | p b | ||
|---|---|---|---|---|---|---|
| TG + TT n (%) | CC n (%) | TG + TT n (%) | CC n (%) | TC + TT vs. CC | ||
| Age (years) | ||||||
| ≤60 | 586 (72.4) | 223 (27.6) | 595 (67.8) | 282 (32.2) | 1.24 (1.01–1.54) | 0.884 |
| >60 | 536 (71.5) | 214 (28.5) | 534 (66.6) | 268 (33.4) | 1.24 (1.00–1.54) | |
| Sex | ||||||
| Male | 793 (72.7) | 298 (27.3) | 787(66.4) | 398 (33.6) | 1.35 (1.13–1.62) | 0.107 |
| Female | 329 (70.3) | 139 (29.7) | 342(69.2) | 152 (30.8) | 1.03 (0.78–1.35) | |
| Smoking status | ||||||
| Current | 371 (72.4) | 141 (27.6) | 354 (66.5) | 178 (33.5) | 1.33 (1.02–1.73) | 0.023 |
| Former | 241 (77.2) | 71 (22.8) | 150 (64.4) | 83 (35.6) | 1.92 (1.31–2.81) | |
| Never | 510 (69.4) | 225 (30.6) | 625 (68.4) | 289 (31.6) | 1.06 (0.85–1.31) | |
| Pack-years smoked | ||||||
| ≥20 | 457 (73.2) | 167 (26.8) | 159 (33.2) | 320 (66.8) | 1.34 (1.04–1.75) | 0.019 |
| <20 | 155 (77.5) | 45 (22.5) | 119 (32.5) | 247 (67.5) | 1.93 (1.28–2.93) | |
| 0 | 510 (69.4) | 225 (30.6) | 272 (32.6) | 562 (67.4) | 1.10 (0.89–1.36) | |
| Drinking status | ||||||
| Ever | 218 (74.4) | 75 (25.6) | 231 (67.5) | 111 (32.5) | 1.48 (1.03–2.11) | 0.427 |
| Never | 904 (71.4) | 362 (28.6) | 898 (67.2) | 439 (32.8) | 1.21 (1.03–1.43) | |
| Family history of cancer | ||||||
| Yes | 91 (70.5) | 38 (29.5) | 98 (66.7) | 49 (33.3) | 1.15 (0.68–1.94) | 0.821 |
| No | 1031 (72.1) | 399 (27.9) | 1031 (67.3) | 501 (32.7) | 1.25 (1.07–1.47) | |
| Family history of lung cancer | ||||||
| Yes | 40 (76.9) | 12 (23.1) | 28 (65.1) | 15 (34.9) | 1.82 (0.67–4.91) | 0.082 |
| No | 1082 (71.8) | 425 (28.2) | 1101 (67.3) | 535 (32.7) | 1.23 (1.06–1.43) | |
| Histological types | ||||||
| Adenocarcinoma | 431 (70.1) | 184 (29.9) | 1129 (67.2) | 550 (32.8) | 1.14 (0.93–1.40) | |
| Squamous cell carcinoma | 385 (73.1) | 142 (26.9) | 1.31 (1.05–1.63) | |||
| Large cell carcinoma | 45 (68.2) | 21 (31.8) | 1.07 (0.63–1.81) | |||
| Small cell lung cancer | 152 (78.8) | 41 (21.2) | 1.83 (1.28–2.63) | |||
| Other carcinomas c | 109 (69.0) | 49 (31.0) | 1.08 (0.76–1.54) | |||
| Stages | ||||||
| I | 136 (68.0) | 64 (32.0) | 1129 (67.2) | 550 (32.8) | 1.04 (0.76–1.42) | |
| II | 105 (71.4) | 42 (28.6) | 1.22 (0.84–1.77) | |||
| III | 357 (72.9) | 133 (27.1) | 1.31 (1.05–1.64) | |||
| IV | 524 (72.6) | 198 (27.4) | 1.30 (1.07–1.57) | |||
a ORs were adjusted for age, sex, smoking status, drinking status, family history of cancer in a logistic regression model; b p value from the multiplicative interaction test between the rs3814058C>T genotypes and selected variables on cancer risk in a logistic regression model; and c Mixed-cell or undifferentiated carcinoma; and Bold numbers mean that the difference or association was statistically significant.