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Pharmacokinetic parameters of lidocaine in rats after intravenous administration of two formulations (n = 6).
| Group | T1/2 (h) | Cmax（μg·mL−1） | Tmax (h) | AUC0-T (h·µg·mL−1) | AUC0-∞ (h·µg·mL−1) |
|---|---|---|---|---|---|
| Injection | 1.2 ± 0.3 | 72.4 ± 12.3 | 0.083 | 110.6 ± 32.1 | 129.7 ± 35.8 |
| Microspheres | 2.6 ± 0.7 * | 45.7 ± 8.4 * | 0.083 | 223.7 ± 45.2 * | 267.3 ± 52.5 * |
* p < 0.05: lidocaine PLGA microspheres vs. lidocaine injection.
