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. 2014 Oct 13;15(10):18407–18421. doi: 10.3390/ijms151018407

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© 2014 by the authors; licensee MDPI, Basel, Switzerland.

This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).

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Radiotherapy-impaired lacrimal secretion and induced lacrimal gland injury in vivo. (A) Gross observation indicating normal and radiotherapy-treated lacrimal glands and the restorative effect of iPSC-CM or MFCM (mouse fibroblasts-derived conditioned medium) on irradiated lacrimal glands; (B) HE staining of irradiated lacrimal glands. Scale bar = 25 µm. One arrow means inflammatory cells, two arrows means the apoptotic acinar cells and three arrows means normal acinar cells; (C–E) Scintigraphic assessment of lacrimal gland secretion function of normal, normal + CM, RT, RT + CM, or RT + MFCM (CM: iPSC-CM, RT: radiotherapy, MFCM: mouse fibroblasts conditioned medium); N = 5. The values are the means ± SD. * p < 0.01.