Ultramicrostructural restoration by iPSC-CM. (A) A TEM image revealing the lacrimal gland ultramicrostructure in normal, normal + CM, RT, RT + CM, or RT + MFCM (normal + CM: non irradiated after iPSC-CM treatment, RT: radiotherapy, RT + CM: radiotherapy after iPSC-CM treatment, RT + MFCM: radiotherapy after mouse fibroblasts conditioned medium treatment); N = 5; (B) Western blot of the protein level of MDK, SFRP2, CXCL2 and LRRC15 in iPSC-CM and MFCM (MFCM: mouse fibroblasts conditioned medium); (C) Quantification of the relative density of western blot results. N = 5. Values are means ± SEM. ** p < 0.01, *** p < 0.001.