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. 2014 Oct 23;15(10):19281–19306. doi: 10.3390/ijms151019281

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© 2014 by the authors; licensee MDPI, Basel, Switzerland.

This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).

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The sequence showed that two putative IRF-1 binding sites are located in the PSR promoter (upper panel). Putative transcription factor (TF) binding sites were identified with the TFSEARCH program (score setting = 75). There are two potential IRF-1 binding elements in the zebrafish 900-bp PSR promoter, and the consensus sequences (5'-G(A)AAA^G/_C^T/_CGAAA^G/_C^T/_C-3') of the IRF-1 transcription factor binding sites were located at positions −428 and −31 (red) relative to the putative zfPSR translation start site (bent arrow). The codes and flanked numbers depicted in blue color represent the TFSEARCH transcription factor identifier and Threshold score, respectively. The green and purple codes showed the region of Goldberg-Hogness (TATA) box and CAAT box, respectively. The lower panel shows a schematic representation of the PSR gene promoter, and the positions of putative IRF-1 binding sites on the fragment are indicated by arrows.