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. Author manuscript; available in PMC: 2014 Nov 11.
Published in final edited form as: Nature. 2014 Jun 29;513(7518):422–425. doi: 10.1038/nature13448

Figure 3. The number and spectrum of substitution mutations in individual organoids.

Figure 3

(A) The spectrum of base substitution mutations in each organoid. (B, left) The absolute number of genome-wide substitutions is shown. When adjusted for sensitivity, the range of the mutation burden per organoid genome is 179 to 1190 (mean 609) substitutions (see Supplementary Table 1). (B, right) The number of CpG > TpG substitutions. Grey bars: mouse 1. White bars: mouse 2. (C) Mutational spectrum of embryonic variants.