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(a) OC99 plasma hemoglobin (Hbp) concentration versus tissue oxygen tension (tPO2). (b) OC99 Hbp concentration versus mean pulmonary artery (PAP) pressure. (c) Change in PAP when 0.65 g/kg OC99 is administered at 30 ml/kg/hr or 10 ml/kg/hr; each symbol represents a different dog. Solid circles: Hextend without OC99; open circles: repeat doses of Hextend with increasing concentrations of OC99 administered over 10 minutes. Solid triangle: Hextend with OC99 administered over 30 minutes.
