Table 1.
Comparison of composition of OC99 (Oxapex), HBOC-301 (Oxyglobin), and HBOC-201 (Hemopure).
| OC99 (Oxapex) | HBOC-301 (Oxyglobin) | HBOC-201 (Hemopure) | |
|---|---|---|---|
| Hemoglobin concentration (g/dL) | 6-7 | 12–14 | 12–14 |
| Met-hemoglobin (%) | ≤5% | <10 | <10 |
| P50 (mmHg) | 39 | 40 | 40 |
| pH | 7.2–7.6 | 7.6–7.9 | 7.6–7.9 |
| Endotoxin (EU/mL) | <0.05 | <0.5 | <0.5 |
| Phospholipid (nmol/mL) | nd | <3 | <3 |
| Colloid osmotic pressure (mmHg) | 19 | 42 | 25 |
| Osmolarity (mOsm/kg) | 250–350 | 300 | 300 |
| Tetrameric hemoglobin (%) | >85 | ≤35 | ≤2 |
| Average molecular weight (kDa) | 65 | 200 | 250 |
| Viscosity (centripoise at 37°C) | 1.1 | 1.3 | 1.3 |
| Half-life in humans/animals (hours) | 16–55∗ | 18–43 | 19 |
| Cross-linking agent | bis (3,5-dibromosalicyl) fumarate. | gluteraldehyde | gluteraldehyde |
| Storage conditions (°C) | <25 (without freezing) | 2–30 | 2–30 |
*Dose dependent; nd: nondetectable.