(a).
Parameter (units) | HEX + CTRL | HEX + LOW | HEX + MID | |||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Shock | End-dose | +1hr | End | Shock | End-dose | +1hr | End | Shock | End-dose | +1hr | End | |
PCV (%) | 39.5 (1.3) | 21.3 (1.7)† | 21.3 (1.4)† | 19.9 (1.4)† | 39.3 (1.8) | 20.3 (0.6)† | 19.4 (0.9)† | 19.9 (1.0)† | 42.5 (2.8) | 20.8 (0.9)† | 20.3 (1.1)† | 21.2 (1.3)† |
Total Hb (g/dL) | 13.5 (0.4) | 7.3 (0.6)† | 7.3 (0.5)† | 6.8 (0.5)† | 13.5 (0.6) | 7.1 (0.2)† | 6.7 (0.3)† | 6.9 (0.3)† | 14.5 (0.9) | 7.7 (0.3)† | 7.5 (0.4)† | 7.7 (0.5)† |
Plasma Hb (g/dL) | 0.06 (0.01) | 0.03 (0.01)† | 0.03 (0.01)† | 0.03 (0.01)† | 0.07 (0.02) | 0.15 (0.00)∗† | 0.14 (0.01)∗† | 0.14 (0.00)∗† | 0.07 (0.01) | 0.63 (0.01)∗† | 0.59 (0.02)∗ | 0.53 (0.02)∗† |
| ||||||||||||
MAP (mmHg) | 41.7 (2.3) | 90.3 (6.7)† | 84.7 (7.0)† | 63.1 (7.3)† | 36.9 (1.2) | 96.1 (4.1) | 79.3 (7.0)† | 56.3 (5.1)† | 41.5 (0.9) | 114.3 (6.3)∗ | 107.2 (9.3)∗ | 89.3 (8.3) |
PAP (mmHg) | 14.4 (0.6) | 20.3 (1.9) | 17.3 (1.7)† | 16.8 (1.7)† | 15.2 (1.4) | 21.7 (2.0) | 17.0 (1.4) | 16.0 (1.2)† | 14.7 (0.8) | 22.4 (1.5) | 17.5 (0.9) | 16.1 (1.2)† |
HR (bpm) | 195.7 (10.0) | 187.6 (8.3)† | 196.9 (9.6)† | 209.6 (10.0)† | 213.1 (7.7) | 200.3 (6.7)† | 203.4 (6.9)† | 196.5 (4.1)† | 228.5 (6.3) | 204.6 (6.2)† | 203.0 (8.2)† | 201.5 (8.2)† |
CO (L/min) | 0.4 (0.0) | 1.8 (0.1) | 1.4 (0.1) | 1.0 (0.1)† | 0.4 (0.1) | 1.9 (0.1) | 1.3 (0.1)† | 1.0 (0.1)† | 0.4 (0.0) | 2.0 (0.2) | 1.5 (0.1)† | 1.2 (0.1)† |
| ||||||||||||
O2 extraction (%) | 67.1 (3.4) | 21.3 (4.3) | 36.2 (6.3)† | 55.4 (8.0)† | 66.0 (2.5) | 27.1 (1.3)† | 44.6 (4.6)† | 57.8 (4.0)† | 70.3 (2.7) | 24.4 (2.6)† | 32.8 (5.1)† | 42.3 (5.8)† |
PaO2 (mmHg) | 84.8 (2.6) | 81.5 (2.6) | 80.9 (1.3) | 83.0 (2.6)† | 91.8 (2.8) | 78.8 (1.8) | 83.4 (3.6)† | 86.6 (3.0)† | 86.0 (1.9) | 80.8 (3.1) | 80.7 (3.0) | 82.8 (4.2)† |
PaCO2 (mmHg) | 29.2 (2.1) | 37.5 (1.3) | 34.9 (1.1) | 29.9 (1.6) | 27.6 (1.8) | 38.2 (0.7) | 34.4 (1.5) | 32.0 (1.2) | 26.7 (1.6) | 36.4 (0.5) | 35.7 (1.0) | 32.2 (1.5) |
tPO2 (mmHg) | 1.1 (0.9) | 10.8 (4.4)† | 8.4 (3.5)† | 3.5 (2.8)† | 2.1 (1.1) | 19.3 (5.4)† | 17.0 (4.9)† | 5.9 (2.2)† | 2.8 (1.4) | 19.5 (2.7)† | 19.3 (2.3)∗† | 12.9 (3.0)† |
| ||||||||||||
pHa | 7.20 (0.02) | 7.28 (0.01) | 7.33 (0.01) | 7.34 (0.01) | 7.19 (0.04) | 7.29 (0.02) | 7.36 (0.02)† | 7.33 (0.03) | 7.17 (0.01) | 7.33 (0.02)† | 7.37 (0.01)† | 7.37 (0.03)† |
BE (mM/L) | −17.0 (0.5) | −9.2 (0.6) | −7.3 (0.5) | −9.4 (1.3) | −18.7 (1.3) | −8.8 (1.1) | −6.2 (0.9) | −8.4 (1.5) | −18.7 (0.9) | −6.7 (1.2) | −4.8 (1.3)† | −6.3 (2.2) |
LA (mM/L) | 7.0 (0.4) | 4.8 (0.6)† | 3.8 (0.5)† | 5.0 (1.0)† | 7.3 (0.4) | 4.9 (0.5)† | 3.9 (0.6)† | 5.3 (1.1)† | 7.4 (0.2) | 4.2 (0.4)† | 2.9 (0.4) | 3.4 (0.9) |
SvO2 (%) | 30.7 (2.9) | 74.2 (4.2)† | 60.6 (6.0)† | 42.6 (7.6)† | 32.2 (2.2) | 68.7 (1.3)† | 52.9 (4.4)† | 40.5 (3.9)† | 27.8 (2.6) | 71.8 (2.5)† | 64.1 (4.8)† | 55.1 (5.4)† |