Table 1.
Description of the study population by case-control status and primary tumor site.
| HNSCC by Site | |||||||
|---|---|---|---|---|---|---|---|
| Controls (n= 857) |
HNSCC (n= 674) |
Crude ORa (95% CI) |
Oral Cavity (n = 223) |
Pharynx (n = 333) |
Larynx (n = 118) |
pdifference | |
| Age, mean years (σ) | 61.0 (10.5) | 59.1 (10.5) | --- | 59.0 (12.3) | 58.4 (9.3) | 61.1 (9.8) | 0.06b |
| Race, n (%) | |||||||
| White | 783 (91.5%) | 612 (90.9%) | reference | 198 (88.8%) | 308 (92.8%) | 106 (89.8%) | 0.23c |
| Non-White | 73 (8.5%) | 61 (9.1%) | 1.07 (0.75–1.53) | 25 (11.2%) | 24 (7.2%) | 12 (10.2%) | |
| Cigarette smoking | |||||||
| Never-smoker, n (%) | 328 (38.3%) | 149 (22.1%) | reference | 50 (22.4%) | 91 (27.3%) | 8 (6.8%) | < 0.001c |
| Ever-smoker, n (%) | 529 (61.7%) | 525 (77.9%) | 2.40 (1.90–3.03) | 173 (77.6%) | 242 (72.7%) | 110 (93.2%) | |
| Pack-years, median (range) | 28.5 (0.1–200) | 36.0 (0.2–203) | 1.02 (1.01–1.02) | 36.8 (0.2–147) | 32.0 (0.4–203) | 45 (0.2–150) | < 0.001d |
| Alcohol consumption, n (%) | |||||||
| Non-drinker | 74 (8.7%) | 38 (5.7%) | reference | 15 (6.8%) | 18 (5.4%) | 5 (4.2%) | 0.003c |
| ≤ 2 drinks per day | 518 (60.6%) | 268 (39.9%) | 1.02 (0.67–1.55) | 80 (36.2%) | 155 (46.6%) | 33 (28.0%) | |
| > 2 drinks per day | 263 (30.8%) | 366 (54.5%) | 2.75 (1.80–4.20) | 126 (57.0%) | 160 (48.1%) | 80 (67.8%) | |
| Highest level of education, n (%) | |||||||
| High school or less | 225 (26.3%) | 273 (40.5%) | reference | 104 (46.6%) | 111 (33.3%) | 58 (49.2%) | 0.01c |
| Greater than high school | 631 (73.7%) | 401 (59.5%) | 0.51 (0.41–0.64) | 119 (53.4%) | 222 (66.7%) | 60 (50.9%) | |
| Annual household income, n (%) | |||||||
| < $25,000 | 121 (15.6%) | 135 (23.2%) | reference | 49 (26.1%) | 58 (19.5%) | 28 (28.9%) | < 0.001c |
| $25,000 – $79,999 | 323 (41.6%) | 230 (39.5%) | 0.61 (0.45–0.82) | 89 (47.3%) | 98 (33.0%) | 43 (44.3%) | |
| ≥ $80,000 | 332 (42.8%) | 217 (37.3%) | 0.51 (0.38–0.70) | 50 (26.6%) | 141 (47.5%) | 26 (26.8%) | |
| HPV16 L1 serostatus, n (%) | |||||||
| Negative | 704 (93.7%) | 408 (68.3%) | reference | 163 (85.3%) | 158 (51.8%) | 87 (86.1%) | < 0.001c |
| Positive | 47 (6.3%) | 189 (31.7%) | 6.71 (4.76–9.46) | 28 (14.7%) | 147 (48.2%) | 14 (13.9%) | |
Abbreviations: HNSCC = head and neck squamous cell carcinoma; σ = standard deviation
a
Adjusted for age (matching factor)
b
t-test for difference across primary tumor sites (cases only)
c
Fisher's exact test for difference across primary tumor sites (cases only)
d
Kruskal-Wallis test for difference across primary tumor sites (cases only)