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. Author manuscript; available in PMC: 2014 Nov 11.
Published in final edited form as: Cornea. 2012 Oct;31(10):1141–1147. doi: 10.1097/ICO.0b013e31823f77f5

Table 1.

Univariate Analysis of Baseline Factors Predictive of a Rejection Event* by Baseline Diagnosis

Total** Fuchs’ Dystrophy Pseudophakic/Aphakic
Corneal Edema
Baseline Factors N Cumulative
Incidence
± 95% CI		 Univariate Proportional Hazard
Models		 N Cumulative
Incidence
± 95% CI		 Univariate
p-value		 N Cumulative
Incidence
± 95% CI		 Univariate
p-value
HR 95% CI p-value
Overall 1,090 26% ± 3% 676 22% ± 4% 36 34% ± 6%
RECIPIENT FACTORS
Age 0.59*** 0.74*** 0.89***
   40 – <50 yrs 34 41% ± 21% 1.00 22 42% ± 24% 9 24% ± 29%
   50 – <60 yrs 128 26% ± 8% 0.69 0.35 – 1.38 104 25% ± 9% 20 35% ± 23%
   60 – <70 yrs 284 21% ± 5% 0.53 0.28 – 1.01 201 16% ± 5% 70 33% ± 13%
   70 – <80 yrs 594 28% ± 4% 0.68 0.37 – 1.26 329 23% ± 5% 242 35% ± 7%
   80 – 86 yrs 50 39% ± 19% 0.82 0.37 – 1.84 20 49% ± 25% 28 35% ± 32%
Race1 0.04 0.04 0.93
   White (non-Hispanic) 1,011 25% ± 3% 1.00 651 22% ± 4% 322 33% ± 6%
   African-American 50 36% ± 14% 1.71 1.03 – 2.84 19 41% ± 24% 27 30% ± 19%
Gender 0.06 0.10 0.08
   Male 393 21% ± 4% 1.00 210 17% ± 5% 158 26% ± 7%
   Female 697 29% ± 4% 1.30 0.99 – 1.71 466 25% ± 4% 211 40% ± 8%
History of diabetes2 0.86 0.82 0.37
   No 899 26% ± 3% 1.00 587 22% ± 4% 276 35% ± 7%
   Yes 141 24% ± 8% 0.97 0.66 – 1.42 67 22% ± 10% 69 26% ± 12%
Smoking status at time of surgery 0.07 0.10 0.87
   No 988 26% ± 3% 1.00 628 21% ± 4% 325 34% ± 6%
   Yes 102 35% ± 11% 1.43 0.97 – 2.09 48 33% ± 15% 44 31% ± 16%
Prior use of glaucoma medications/surgery 0.005 0.42 0.35
   No medications and no surgery 920 24% ± 3% 1.00 627 22% ± 4% 259 31% ± 7%
   Medications and no surgery 99 34% ± 10% 1.55 1.06 – 2.28 34 32% ± 17% 61 34% ± 13%
   No medications and surgery 26 31% ± 24% 1.14 0.51 – 2.57 8 13% ± 23% 15 30% ± 25%
   Medications and surgery 45 54% ± 21% 2.16 1.31 – 3.55 7 33% ± 39% 34 61% ± 26%
Recipient Bed size3 0.61*** 0.05*** 0.64***
   ≤7.5 309 26% ± 6% 1.00 148 16% ± 7% 144 38% ± 10%
   7.6 – <8.0 155 30% ± 8% 1.16 0.78 – 1.72 92 30% ± 10% 54 29% ± 15%
   =8.0 523 25% ± 4% 0.99 0.73 – 1.34 365 21% ± 5% 144 31% ± 8%
   >8.0 102 31% ± 10% 1.34 0.87 – 2.08 70 29% ± 12% 27 39% ± 21%
OPERATIVE FACTORS
Vitrectomy 0.003 0.05 0.33
   No 931 25% ± 3% 1.00 645 22% ± 4% 242 33% ± 7%
   Yes 159 36% ± 9% 1.61 1.17 – 2.20 31 38% ± 21% 127 36% ± 10%
Post-operative Intraocular Pressure4(mmHg) 0.98*** 0.46** 0.10***
   ≤ 25 953 26% ± 3% 1.00 608 21% ± 4% 301 35% ± 7%
   >25 130 30% ± 10% 1.11 0.76 – 1.62 63 31% ± 14% 66 27% ± 12%
DONOR FACTORS
Age 0.40*** 0.23*** 0.80***
   12 – <40 years 114 31% ± 10% 1.00 76 30% ± 12% 35 34% ± 17%
   40 – <50 years 122 26% ± 9% 0.85 0.51 – 1.41 65 26% ± 11% 49 34% ± 18%
   50 – <60 years 272 25% ± 6% 0.79 0.51 – 1.21 175 21% ± 7% 88 32% ± 10%
   60 – <70 years 365 27% ± 5% 0.78 0.52 – 1.18 223 20% ± 6% 126 36% ± 10%
   70 – 76 years 217 24% ± 7% 0.73 0.46 – 1.15 137 21% ± 8% 71 33% ± 14%
Race5 0.10 0.03 1.00
   White (non-Hispanic) 1,024 26% ± 3% 1.00 632 21% ± 4% 351 34% ± 6%
   African-American 41 39% ± 18% 1.57 0.92 – 2.70 28 41% ± 22% 10 33% ± 32%
Gender 0.90 0.69 0.55
   Male 716 27% ± 4% 1.00 451 22% ± 4% 238 36% ± 8%
   Female 374 26% ± 5% 1.02 0.78 – 1.32 225 23% ± 6% 131 30% ± 9%
Cause of death 0.81 0.56 0.57
   Cardio/Stroke 659 25% ± 4% 1.00 418 22% ± 4% 214 30% ± 7%
   Cancer 207 28% ± 7% 1.10 0.79 – 1.52 118 18% ± 8% 79 43% ± 13%
   Trauma 96 27% ± 10% 1.08 0.69 – 1.69 57 25% ± 13% 35 33% ± 17%
   Respiratory 78 31% ±11% 1.32 0.84 – 2.07 54 29% ±14% 21 36% ±22%
   Other 50 26% ± 15% 1.01 0.55 – 1.87 29 21% ± 15% 20 36% ± 30%
History of diabetes 0.62 0.39 0.74
   No 891 26% ± 3% 1.00 552 22% ± 4% 298 34% ± 6%
   Yes 199 28% ± 7% 1.08 0.79 – 1.48 124 25% ± 8% 71 33% ± 14%
Baseline ECD (cells/mm2) 0.43*** 0.55*** 0.44***
   ≤2500 324 24% ± 5% 1.00 215 20% ± 5% 101 32% ± 10%
   2501 – 2999 625 27% ± 4% 1.06 0.80 – 1.41 370 22% ± 5% 227 35% ± 8%
   ≥3000 141 29% ± 9% 1.18 0.79 – 1.77 91 27% ± 10% 41 35% ± 15%
Tissue retrieval 0.51 0.90 0.59
   Enucleation 218 27% ± 7% 1.00 152 24% ± 8% 57 33% ± 15%
   In situ 872 26% ± 3% 1.11 0.81 – 1.53 524 22% ± 4% 312 34% ± 6%
Tissue refrigerated 0.82 0.63 0.55
   No 255 26% ± 6% 1.00 157 24% ± 8% 91 30% ± 11%
   Yes 835 27% ± 3% 1.04 0.77 – 1.39 519 22% ± 4% 278 35% ± 7%
Time from death to preservation 0.87 0.74 0.74
   0–4 hrs 206 29% ± 7% 1.00 120 28% ± 10% 76 29% ± 11%
   5–8 hrs 577 26% ± 4% 0.86 0.62 – 1.19 364 20% ± 4% 187 36% ± 8%
   9–10 hrs 165 26% ± 8% 0.90 0.59 – 1.37 108 21% ± 8% 51 39% ± 16%
   11–12 hrs 113 25% ± 9% 0.83 0.50 – 1.35 67 25% ± 12% 43 23% ± 15%
   >12 hrs 29 30% ± 18% 1.07 0.51 – 2.25 17 24% ± 21% 12 41% ± 32%
Time from death to surgery 0.38 0.65 0.54
   0–2 days 146 33% ± 9% 1.00 85 28% ± 11% 56 44% ± 17%
   3–4 days 597 26% ± 4% 0.78 0.55 – 1.11 358 22% ± 5% 205 32% ± 8%
   5–8 days 347 24% ± 5% 0.81 0.56 – 1.19 233 21% ± 6% 108 32% ± 10%
RECIPIEN/DONOR FACTORS
ABO Compatible6 0.32 0.52 0.39
   No 364 25% ± 5% 1.00 229 21% ± 6% 122 31% ± 11%
   Yes 638 27% ± 4% 1.15 0.87 – 1.52 390 22% ± 5% 220 36% ± 8%
Rh Compatible7 0.53 0.69 0.27
   No 125 28% ± 9% 1.00 84 18% ± 8% 36 50% ± 24%
   Yes 832 25% ± 3% 0.89 0.61 – 1.30 517 22% ± 4% 280 32% ± 6%
ABO/Rh Compatible 8 0.56 0.81 0.48
   ABO and Rh Compatible 494 25% ± 4% 1.00 300 22% ± 5% 171 33% ± 8%
   ABO compatible, Rh incompatible 82 30% ± 11% 1.27 0.81 – 1.99 54 20% ± 11% 24 51% ± 27%
   ABO incompatible, Rh compatible 294 25% ± 6% 0.91 0.67 – 1.25 188 21% ± 7% 95 33% ± 11%
   Neither ABO nor Rh compatible 43 23% ± 16% 0.82 0.40 – 1.69 30 14% ± 12% 12 50% ± 52%
*

Includes both probable and/or definite rejection events

**

Includes 45 subjects with variety of diagnoses: 12 with interstitial keratitis, 7 with posterior polymorphous dystrophy, 6 with perforating corneal injury and 20 with other causes of endothelial failure

***

P-value from model fit with continuous factor

1

Excludes 13 Hispanics, 8 Asian and 8 other race recipients, because groups were too small to analyze separately

2

Unknown for 50 subjects

3

One subject with missing value for bed size

4

7 subjects with missing value for post-operative IOP

5

Excludes 11 Hispanics, 3 Asian and 11 other race donors, because groups were too small to analyze separately

6

88 subjects with missing ABO type

7

133 subjects with missing Rh blood type

8

177 subjects with missing ABO/Rh type