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Met has a synergistic anti-proliferative effect with 5-Fu in Bel/Fu cells. (A and B) Bel/Fu cells were singly or jointly treated with 100 μg/ml 5-Fu or 10 mM met. A Cell Counting kit-8 assay was performed to determine cell viability (**P<0.01, compared with the 5-Fu and Met). (C) Morphology of the Bel/Fu cells following treatment with Met for 48 h (magnification, ×10). 5-Fu, 5-fluorouracil; Met, metformin.
