Table 3.
Model Predictions of Lung Delivery During Cyclic Breathing
| Aerosols | MMAD lung inlet (μm) | DFTBa | DFalveolara | DFlunga | Lung exhaled doseb |
|---|---|---|---|---|---|
| CM wye T1 | |||||
| MMAD=880 nm | 0.70 | 8.7 | 9.0 | 17.8 | 24.5 |
| MMAD=1.78 μm | 1.23 | 12.5 | 7.3 | 19.7 | 14.7 |
| MMAD=4.9 μm | 1.46 | 4.6 | 2.2 | 6.8 | 3.5 |
| CM wye T2 | |||||
| MMAD=880 nm | 0.70 | 15.6 | 17.3 | 32.9 | 44.5 |
| MMAD=1.78 μm | 1.24 | 24.1 | 14.1 | 38.2 | 27.7 |
| MMAD=4.9 μm | 1.53 | 9.2 | 4.3 | 13.5 | 6.4 |
| SL wye T1 | |||||
| MMAD=880 nm | 0.70 | 10.8 | 11.3 | 22.1 | 32.4 |
| MMAD=1.78 μm | 1.28 | 18.3 | 9.5 | 27.8 | 20.2 |
| MMAD=4.9 μm | 2.00 | 10.1 | 3.3 | 13.3 | 5.0 |
| SL wye T2 | |||||
| MMAD=880 nm | 0.70 | 16.4 | 20.0 | 36.4 | 43.9 |
| MMAD=1.78 μm | 1.28 | 28.0 | 17.2 | 45.2 | 27.0 |
| MMAD=4.9 μm | 1.90 | 13.9 | 5.7 | 19.6 | 6.4 |
The table presents model predictions of lung delivery during cyclic breathing, including the MMAD of the polydisperse aerosol entering the lungs, deposition fraction (DF) in the TB, alveolar, and total lung, as well as exhaled dose exiting the lungs.
a
All DFs are in terms of initial dose injected at the delivery circuit inlet and therefore take into account losses in the delivery system (wye and ETT).
b
Percentage of aerosol that enters the lungs and is then exhaled back into the delivery system and out the expiratory line.