Table 3.
The dysregulated expression and target genes or pathways of miR-375 in cancer.
| Type of cancer | miR-375 expression | Validated target genes or pathways | Reference |
|---|---|---|---|
| HNSCC | Down | MTDH, LDHB, IGF1R | [37, 38, 45, 46] |
| ESCC | Down | PDK1, IGF1R | [23, 40] |
| Gastric cancer | Down | JAK2-STAT3, PDK1, YWHAZ, ERBB2 | [11, 39, 47–49] |
| HCC | Down | AEG-1, ATG7, YAP1 | [10, 50–52] |
| Lung cancer | Down | YAP1, CLDN1 | [53, 54] |
| Pancreatic cancer | Down | PDK1 | [55, 56] |
| Colorectal cancer | Down | PIK3CA | [57, 58] |
| Cervical cancer | Down | SP1 | [59, 60] |
| Breast cancer | Up | RASD1, IGF1R | [15, 61] |
| Prostate cancer | Up | Sec23A | [14] |
HNSCC: head and neck squamous cell carcinomas; ESCC: esophageal squamous cell carcinoma; HCC: hepatocellular carcinoma.