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. 2014 Nov 11;5:242. doi: 10.3389/fphar.2014.00242

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Copyright © 2014 Samokhvalov, Vriend, Jamieson, Akhnokh, Manne, Falck and Seubert.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Treatment with 14,15-epoxyeicosatrienoic acids (EET) recapitulated protective effects of UA-8 in LPS-induced cytotoxicity. NCMs were treated with LPS (1 μg/ml) and/or 14,15-EET (1 μm) in the presence or absence of 14,15-EEZE (10 μm) for 24 h. (A) Treatment with 14,15-EET significantly improved LPS-decreased cell viability. (B,C) 14,15-EET significantly attenuated LPS-triggered inflammatory response as seen with reductions in NF-kB DNA binding activity and TNFα release. (D) 14,15-EET induced an increase in PPARγ DNA binding activity and significantly prevented LPS-triggered drop in PPARγ DNA binding activity. Values are represented as mean ± SEM, N = 3–4. Significance was set at P < 0.05. * Significantly different from control. # Significantly different from LPS-treated cells.