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. Author manuscript; available in PMC: 2015 Jan 1.
Published in final edited form as: Curr Pharm Biotechnol. 2014;15(7):673–683. doi: 10.2174/1389201015666140915152706

Figure 4.

Figure 4

Chemical and structural modifications to enhance microdevice adhesion and increase residence time. A. Fluorescence micrograph of FITC-lectin (green) asymmetrically coated onto the drug-releasing side of microdevices for targeted bioadhesion to the intestinal mucosa with fluorescently labeled BSA shown in blue [34]. B. Microdevices with microposts designed to penetrate the mucus membrane surrounding a drug reservoir [57]. C. Planar nanowire-coated microparticles dramatically increase surface area and enhance microdevice adhesion through increased non-covalent interactions [76]. D. Self-folding microdevices shown before (i) and after (ii) exposure to water are designed to mechanically attach to intestinal tissue [60]. Reproduced with permission.