Table 1. Analysis of five rare CARD14 variants using Fisher's exact test.

	p.Met119Val				p.Arg166His				p.Ala216Thr				p.Thr591Met				p.Arg682Trp				Combination of five variants
	AA	Aa	aa	Allele frequency (a)	AA	Aa	aa	Allele frequency (a)	AA	Aa	aa	Allele frequency (a)	AA	Aa	aa	Allele frequency (a)	AA	Aa	aa	Allele frequency (a)	AA	Aa	aa	Allele frequency (a)
P-PsV	94	0	0		94	0	0		93	1	0	0.005	94	0	0		94	0	0		93	1	0	0.005
L-PsV	80	0	0		80	0	0		80	0	0		79	1	0	0.006	80	0	0		79	1	0	0.006
PsV	174	0	0		174	0	0		173	1	0	0.003	173	1	0	0.003	174	0	0		172	2	0	0.006
GPP	61	1	0	0.008	61	1	0	0.008	62	0	0		62	0	0		61	1	0	0.008	59	3	0	0.024
Psoriasis	235	1	0	0.002	235	1	0	0.002	235	1	0	0.002	235	1	0	0.002	235	1	0	0.002	231	5	0	0.011
Control	365	0	0		365	0	0		365	0	0		365	0	0		365	0	0		365	0	0
P (Psoriasis versus control)				0.393 (0.561)				0.393 (0.561)				0.393 (0.561)				0.393 (0.561)				0.393 (0.561)				0.009 (0.09)
P (PsV versus GPP)				0.263 (0.438)				0.263 (0.438)				1 (1)				1 (1)				0.263 (0.438)				0.115 (0.438)
P (PsV versus control)				1 (1)				1 (1)				0.322 (0.998)				0.322 (0.998)				1 (1)				0.104 (0.998)
P (GPP versus control)				0.145 (0.29)				0.145 (0.29)				1 (1)				1 (1)				0.145 (0.29)				0.003 (0.03)
P (P-PsV versus L-PsV)				1 (1)				1 (1)				1 (1)				0.46 (1)				1 (1)				1 (1)

Abbreviations: GPP, generalized pustular psoriasis; L-PsV, late-onset psoriasis vulgaris; P-PsV, pediatric-onset psoriasis vulgaris; PsV, psoriasis vulgaris (including P-PsV and L-PsV); Ps, psoriasis (including PsV and GPP).

In the table, there are two types of P-values—nominal and corrected, of which the latter are in parentheses, calculated by false-discovery rate.