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. 2014 Aug 14;134(12):2918–2927. doi: 10.1038/jid.2014.262

Figure 5.

Figure 5

Human papilloma virus (HPV) infection hampers the enhanced attraction of immune cells by CD40-stimulated epithelial cells (ECs). (a) ELISA for IL8 and RANTES in cleared supernatants from IFNγ-pre-stimulated HPV-positive foreskin, vaginal, and cervical EC cultures (n=5–12) cocultured for 24 hours with control or CD40L-expressing L cells in the presence of IFNγ. ** Indicates P<0.005 using unpaired Welch-corrected t-test. (b) Example of a representative experiment of the production of IL8 and RANTES in cleared supernatants of vaginal EC donors used for the migration assay by ELISA, and peripheral blood mononuclear cell (PBMC) migration toward these cleared supernatants from vaginal EC donors prepared for the migration assay. (c) Migration index of total PBMC toward indicated HPV-positive foreskin, vaginal, and cervical EC supernatants of four independent experiments. NS indicates P is not significant.