Skip to main content
. 2014 Oct 15;16(21):5636–5639. doi: 10.1021/ol502708z

Table 5. Scope of the Nucleophilic Compatibility.

graphic file with name ol-2014-02708z_0012.jpg

graphic file with name ol-2014-02708z_0013.jpg

a

1 equiv of 1a, 1.2 equiv of NaN3, dry CH3CN (0.1 M), 76 °C, 2 h.

b

1 equiv of 1a, 1.5 equiv of NaSCN, dry CH3CN (0.1 M), 76 °C, 1 h.

c

1 equiv of 1a, 1.2 equiv of potassium phthalimide, 10 mol % of 18-crown-6, dry toluene (0.2 M), 100 °C, 1 h.

d

1 equiv of 1a, 1 equiv of Na2CO3, DMF/CH3CN/H2O (0.15 M), 25 °C, 12 h.

e

1 equiv of 1a, 1.01 equiv of 1-methylimidazole, dry THF (0.2 M), 25 °C, 12 h.