Table 2. Protein Regulations in FECD Tissue^a.

	accession no.	nameb	GOc	p-value	method
Up-regulated Proteins
1	O00468	Agrin	E	0.047, 0.001	XIC, iTRAQ
2	P05090	Apolipoprotein D	E	0.045, 0.001	XIC, iTRAQ
3	Q9Y240	C-type lectin domain family 11 member A	E/I	0.001	iTRAQ
4	Q9NQ79	Cartilage acidic protein 1	E	0.001	iTRAQ
5	P10909	Clusterin	E/I	0.000	iTRAQ
6	P12111	Collagen alpha-3(VI) chain	E	0.001	iTRAQ
7	P01024	Complement C3	E	0.016	iTRAQ
8	P07585	Decorin	E	0.027	iTRAQ
9	O95967	EGF-containing fibulin-like extracellular matrix protein 2	E	0.044	iTRAQ
10	Q9Y6C2	EMILIN-1	E	0.022	iTRAQ
11	P01876	Ig alpha-1 chain C region	E	0.010	iTRAQ
12	O60938	Keratocan	E	0.027, 0.048	XIC, iTRAQ
13	O15232	Matrilin-3	E	0.011	iTRAQ
14	Q15582	Transforming growth factor-beta-induced protein ig-h3	E	0.015	iTRAQ
Down-regulated Proteins
1	P02452	Collagen alpha-1(I) chain	E	0.003	iTRAQ
2	P08123	Collagen alpha-2(I) chain	E	0.039	iTRAQ
3	P02458	Collagen alpha-1(II) chain	E	0.009	XIC
4	P02461	Collagen alpha-1(III) chain	E	0.02, 0.003	XIC, iTRAQ
5	P53420	Collagen alpha-4(IV) chain	E	0.035	XIC
6	P05997	Collagen alpha-2(V) chain	E	0.032	iTRAQ
7	P35555	Fibrillin-1	E	0.005, 0.021	XIC, iTRAQ
8	P04264	Keratin, type II cytoskeletal 1	I	0.006	XIC
9	P35527	Keratin, type I cytoskeletal 9	I	0.024	XIC
10	P13645	Keratin, type I cytoskeletal 10	I	0.031, 0.002	XIC, iTRAQ
11	P14555	Phospholipase A2, membrane associated	I	0.004	iTRAQ
12	P24821	Tenascin	E	0.047	iTRAQ

^aProteins regulated with a p-value below 0.05 and quantified based on a minimum of 3 unique peptides.

^bProteins in bold are within the most abundant proteins listed in Table 1.

^cGene Ontology terms (GO) indicate whether the proteins are extracellularly (E) or intracellularly (I).