Table 1. Similar Pattern of Fold Change in the Top 100 Ranked Proteins Shared between the Amyloid and Nonamyloid Prion Disease Phenotypes.

			amyloid		nonamyloid
IDa	gene	shared proteins	Δ foldb	rankc	Δ fold	rank
P04925	PRNP	Major prion protein (PrP)	↑ 91.0	36	↑ 2.0	86
Q02105	C1QC	Complement C1q subcomponent subunit C	↑ 17.7	8	↑ 27.6	4
P29699	AHSG	α-2-HS-glycoprotein	↑ 13.7	20	↑ 26.7	5
P20152	VIM	Vimentin	↑ 11.9	66	↑ 7.9	46
P98086	C1QA	Complement C1q subcomponent subunit A	↑ 9.4	7	↑ 11.7	4
P14106	C1QB	Complement C1q subcomponent subunit B	↑ 7.8	32	↑ 10.2	1
Q61838	A2M	α-2-macroglobulin	↑ 6.0	28	↑ 2.8	11
P03995	GFAP	Glial fibrillary acidic protein	↑ 5.8	1	↑ 8.9	44
Q8BJI1	SLC6A17	Na and Cl-dependent neurotransmitter transporter NTT4	↑ 5.0	51	↑ 7.4	65
Q99L04	DHRS1	Dehydrogenase/reductase SDR family member 1	↑ 2.3	78	↑ 3.2	34
P26443	GLUD1	Glutamate dehydrogenase 1, mitochondrial	↑ 1.6	99	↑ 1.5	25
Q9R0P9	UCHL1	Ubiquitin carboxyl-terminal esterase L1	↓ −1.5	77	↓ −1.3	89
P62761	VSNL1	Visinin-like protein 1	↓ −1.9	31	↓ −1.3	60
P18760	CFL1	Cofilin-1	↓ −2.3	12	↓ −1.4	62
Q9R0P5	DSTN	Destrin	↓ −2.5	41	↓ −1.6	94
Q5PR73	DIRAS2	GTP-binding protein Di-Ras2	↓ −2.7	92	↓ −2.3	88
Q9QZ23	NFU1	NFU iron–sulfur cluster scaffold homologue, mitochondrial	↓ −3.1	74	↓ −3.5	67

^aProtein identifiers and gene names are from www.uniprot.org.

^bFold change in abundance relative to uninfected control.

^cRank out of 1567 identified proteins based upon lowest p value, highest fold change, best count combination, and lowest coefficient of variation.