Table 6. Proteins Associated with Cell Death and Survival in Prion-Infected Mice with the Amyloid Disease Phenotype.

			amyloid		nonamyloid
IDa	gene	cell death and survival proteinsb	Δ foldc	rankd	Δ fold	rank
P04925	PRNP	Major prion protein (PrP)	↑ 91.0	36	↑ 2.0	86
P20152	VIM	Vimentin	↑ 11.9	66	↑ 7.9	46
P07759	SPI2	Serine protease inhibitor A3K	↑ 10.0	29	---	---
P98086	C1QA	Complement component 1, q, A chain	↑ 9.4	7	↑ 11.7	4
Q06890	CLU	Clusterin (apolipoprotein J or apoJ)	↑ 8.2	3	---	---
P08226	APOE	Apolipoprotein E	↑ 7.6	5	---	---
P61148	FGF1	Fibroblast growth factor 1 (acidic)	↑ 7.4	47	---	---
Q61838	A2M	α-2-macroglobulin	↑ 6.0	28	↑ 2.8	11
P03995	GFAP	Glial fibrillary acidic protein	↑ 5.8	1	↑ 8.9	44
Q8BTM8	FLNA	Filamin A, α	↑ 5.4	49	---	---
Q78PY7	SND1	Staphylococcal nuclease and tudor domain	↑ 4.7	30	---	---
Q00612	G6PD	Glucose-6-phosphate dehydrogenase	↑ 4.5	46	---	---
Q921I1	TF	Transferrin	↑ 4.5	9	---	---
Q61292	LAMB2	Laminin, β 2 (laminin S)	↑ 3.0	70	---	---
P18242	CTSD	Cathepsin D	↑ 2.5	43	---	---
Q9CZX8	RPS19	Ribosomal protein S19	↑ 2.1	97	---	---
Q9DCN2	CYB5R3	Cytochrome b5 reductase 3	↑ 2.0	40	---	---
P26443	GLUD1	Glutamate dehydrogenase 1, mitochondrial	↑ 1.6	99	↑ 1.5	25
Q9R0P9	UCHL1	Ubiquitin carboxyl-terminal esterase L1	↓ −1.5	77	↓ −1.3	89
O08756	HSD17B10	Hydroxysteroid (17-β) dehydrogenase 10	↓ −1.9	57	---	---
P09671	SOD2	Superoxide dismutase 2, mitochondrial	↓ −2.0	58	---	---
P01831	THY1	Thy-1 cell surface antigen	↓ −2.0	38	---	---
Q91XV3	BASP1	Brain, membrane attached signal protein 1	↓ −2.0	11	---	---
P60824	CIRBP	Cold inducible RNA binding protein	↓ −2.4	89	---	---
Q60631	GRB2	Growth factor receptor-bound protein 2	↓ −2.6	84	---	---
O35658	C1QBP	Complement component 1, q binding protein	↓ −2.6	76	---	---
P60766	CDC42	Cell division cycle 42	↓ −3.5	22	---	---
		Calcium associated proteinse
P07356	ANXA2	Annexin A2	↑ 42.7	14	---	---
P13020	GSN	Gelsolin	↑ 4.9	45	---	---
Q6PHS9	CACNA2D	Calcium channel, voltage-dependent, α 2/Δ 2	↑ 3.4	53	---	---
Q64331	MYO6	Myosin VI	↑ 2.9	62	---	---
Q91ZX7	LRP1	Low density lipoprotein receptor-related protein 1	↑ 2.5	13	---	---
P48962	SLC25A4	ADP/ATP translocase 1	↓ −1.4	88	---	---
P60879	SNAP25	Synaptosomal-associated protein, 25 kDa	↓ −1.5	75	---	---
Q60932	VDAC1	Voltage-dependent anion channel 1	↓ −1.7	70	---	---
P62761	VSNL1	Visinin-like 1	↓ −1.9	31	↓ −1.3	60
Q61171	PRDX2	Peroxiredoxin 2	↓ −1.9	22	---	---
Q63810	PPR3R1	Calcineurin subunit B type 1	↓ −2.0	65	---	---
O35526	STX1A	Syntaxin 1A (brain)	↓ −2.1	42	---	---
P18760	CFL1	Cofilin 1 (nonmuscle)	↓ −2.3	12	↓ −1.4	62
P49615	CDK5	Cyclin-dependent kinase 5	↓ −2.4	100	---	---
P60904	DNAJC5	DnaJ (Hsp40) homologue, subfamily C, member 5	↓ −2.4	91	---	---

^aProtein identifiers and gene names are from www.uniprot.org.

^bProteins shown in bold are unique to cell death and were not found associated with any other molecular and cellular functions identified by IPA in the nonamyloid disease phenotype.

^cFold change in abundance relative to uninfected control.

^dRank out of 1567 identified proteins based upon lowest p value, highest fold change, best count combination, and lowest coefficient of variation. The dashed line (---) indicates the protein was not among the top 100 ranked proteins.

^eProteins involved in calcium binding or calcium-mediated transport, regulation, and signaling.