Table 3. Difference in percent mammographic density (95% confidence interval) by metabolic syndrome status and components of metabolic syndrome among postmenopausal women stratified by state (EsMaestras, 2006).
| Jalisco (N=142) | Veracruz (N=180) | |||||||
|---|---|---|---|---|---|---|---|---|
| N (%) exposed |
Age-adjusteda | MV-adjustedb | MV-adjusted with BMI c |
N (%) exposed |
Age-adjusteda | MV-adjustedb | MV-adjusted with BMI c |
|
| Metabolic Syndrome | ||||||||
| Harmonized definition (waist≥88cm) | 73 (51.4) | -2.60 (-7.32, 2.12) | -2.87 (-8.31, 2.58) | -0.62 (-6.76, 5.53) | 70 (38.9) | -3.68 (-7.56, 0.20) | -2.70 (-6.89, 1.48) | -1.63 (-5.97, 2.71) |
| Harmonized definition (waist≥80cm) | 85 (59.9) | 1.64 (-3.18, 6.46) | 1.79 (-3.62, 7.2) | 3.98 (-1.71, 9.68) | 80 (44.4) | -4.69* (-8.51, -0.86) | -3.45 (-7.61, 0.71) | -2.71 (-6.93, 1.51) |
| Individual metabolic syndrome components | ||||||||
| Abdominal obesity (waist≥88cm) | 98 (69.0) | -7.50* (-12.45, -2.54) | -6.61* (-12.47, -0.74) | -5.03 (-11.92, 1.86) | 110 (61.1) | -6.33* (-10.09, -2.58) | -5.55* (-9.67, -1.44) | -4.69 (-9.70, 0.33) |
| Abdominal obesity (waist≥80cm) | 129 (90.9) | -3.14 (-11.29, 5.01) | -0.76 (-9.91, 8.39) | 2.11 (-7.50, 11.71) | 160 (88.9) | -6.13* (-12.06, -0.2) | -3.28 (-9.69, 3.12) | -0.83 (-7.79, 6.13) |
| High fasting triglycerides (≥150mg/dl) | 77 (54.2) | 0.67 (-4.06, 5.39) | -1.14 (-6.69, 4.41) | 0.64 (-5.10, 6.38) | 61 (33.9) | 0.38 (-3.62, 4.38) | 0.63 (-3.73, 4.99) | 0.92 (-3.41, 5.25) |
| Low HDL (<50mg/dl) | 93 (65.5) | 0.66 (-4.29, 5.61) | 0.87 (-5.01, 6.75) | 2.57 (-3.55, 8.70) | 77 (42.8) | 1.57 (-2.23, 5.38) | 3.42 (-0.72, 7.56) | 3.49 (-0.61, 7.58) |
| High blood pressure (SBP≥130mmgHg or DBP≥85mmgHg) | 73 (51.4) | -0.89 (-5.63, 3.85) | -0.06 (-5.81, 5.69) | 2.01 (-4.06, 8.07) | 81 (45.0) | -1.02 (-4.96, 2.92) | -0.03 (-4.34, 4.28) | 0.81 (-3.54, 5.15) |
| High fasting glucose (≥100mg/dl) | 40 (28.2) | -3.87 (-9.14, 1.40) | -3.55 (-10.04, 2.93) | -2.66 (-9.37, 4.05) | 50 (27.8) | -3.72 (-7.92, 0.47) | -2.11 (-6.69, 2.47) | -1.53 (-6.11, 3.05) |
| High fasting glucose (≥110mg/dl) | 24 (16.9) | -3.56 (-9.85, 2.73) | -3.93 (-11.53, 3.67) | -2.23 (-10.13, 5.67) | 28 (15.6) | -4.60 (-9.76, 0.55) | -3.99 (-9.54, 1.56) | -3.89 (-9.38, 1.61) |
a
Model 1: adjusted for age at mammogram (continuous)
b
Model 2: Model 1 and family history of breast cancer (yes, no), history of bbd (yes, no), age at menarche (<12, 12, 13, 14+, unknown), oral contraceptive use (never, ever <5 , ever 5+), number of full term pregnancies (nulliparous,1,2,3,4+), age at first pregnancy (nulliparous, <20, 20-24, 25-29, 30+), alcohol intake (none, <0.1, 0.1-0.2, 0.2+ drinks per day), smoking status (never, ever), age at menopause (<40, 40-44, 45-49, 50+, unknown), and SES (low, medium, high)
c
Model 3: Model 2 and BMI at mammogram (continuous)
*
p<0.05