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. 2014 Nov 5;9:5131–5141. doi: 10.2147/IJN.S71074

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© 2014 Duan et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License

The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

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LC3-I/LC3-II conversion in HUVECs treated with Nano-SiO₂.

Notes: (A) The autophagy marker LC3 protein is detected by Western blot analysis. (B) Relative densitometric analysis showed that the ratio of LC3-II/LC3-I significantly elevated in a dose-dependent manner. ANOVA followed by the LSD method are used for the data analysis. Data are expressed as the mean ± standard deviation from three independent experiments (*P<0.05).

Abbreviations: LC3, microtubule-associated protein 1 light chain 3β; GAPDH, glyceraldehyde 3-phosphate dehydrogenase; HUVECs, human umbilical vein endothelial cells; Nano-SiO₂, silica nanoparticles; ANOVA, one-way analysis of variance; LSD, least significant difference.