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. 2014 Nov 5;9:5131–5141. doi: 10.2147/IJN.S71074

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© 2014 Duan et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License

The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

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Effects of Nano-SiO₂ on the PI3K/Akt/mTOR signaling pathway.

Notes: (A) The expression of p-PI3K, PI3K, p-Akt, Akt, p-mTOR, and mTOR were measured by Western blot assay. (B) Relative densitometric analysis of the protein bands was performed and presented. Nano-SiO₂ inhibited the PI3K/Akt/mTOR signaling pathway. ANOVA followed by the LSD method are used for the data analysis. Data are expressed as the mean ± standard deviation from three independent experiments (*P<0.05).

Abbreviations: PI3K, phosphoinositide 3-kinase; Akt, protein kinase B; mTOR, mammalian target of rapamycin; GAPDH, glyceraldehyde 3-phosphate dehydrogenase; Nano-SiO₂, silica nanoparticles; ANOVA, one-way analysis of variance; LSD, least significant difference.