Table 2. Glomerular Structural Parameters.
Case | Sex | Age (year) | %NFPC/glom | Vv(Inc/PC) | Vv(Inc/Mes) | Vv(Inc/Endo) | Vv(Inc/FPC) | FPW* (nm) |
1 | F | 8 | 20 | 0.28 | 0.03 | 0.08 | 0.50 | 524 |
2 | F | 11 | 50 | 0.43 | 0.02 | 0 | 0.62 | 426 |
3 | F | 12 | 52 | 0.21 | 0 | 0 | 0.42 | 372 |
4 | F | 13 | 45 | 0.20 | 0 | 0.03 | 0.42 | 464 |
5 | F | 13 | 21 | 0.26 | 0.03 | 0.03 | 0.68 | 663 |
6 | F | 14 | 22 | 0.38 | 0.07 | 0.02 | 0.53 | 602 |
7 | F | 16 | 13 | 0.51 | 0.03 | 0.02 | 0.67 | 461 |
8 | F | 34 | 55 | 0.43 | 0.01 | 0.01 | 0.70 | 620 |
9 | F | 34 | 100 | 0 | 0 | 0.01 | 0 | 427 |
10 | F | 39 | 58 | 0.21 | 0.01 | 0 | 0.35 | 654 |
11 | F | 39 | 100 | 0.02 | 0.01 | 0 | 0 | 441 |
12 | F | 63 | 68 | 0.16 | 0.04 | 0.06 | 0.48 | 673 |
13 | M | 7 | 8** | 0.21 | 0.01 | 0.09 | 0.58 | 369 |
14 | M | 16 | 0 | 0.44 | 0.10 | 0.37 | 0.56 | 551 |
15 | M | 18 | 0 | 0.50 | 0.16 | 0.21 | 0.61 | 823 |
16 | M | 23 | 0 | 0.34 | 0.56 | 0.27 | 0.65 | 714 |
Abbreviations: %NFPC/glom = % non-Fabry podocytes per glomerulus; Vv(Inc/PC) = volume fraction of GL3 inclusions per podocyte; Vv(Inc/Mes) = volume fraction of GL3 inclusions per mesangial cell; Vv(Inc/Endo) = volume fraction of GL3 inclusions per endothelial cell; Vv(Inc/FPC) = volume fraction of GL3 inclusions per Fabry podocytes; FPW = foot process width; F = female; M = male; *Normal values for FPW obtained from biopsies from 6 healthy living donors was 406±34 nm. **The biopsy contained two very small podocyte profiles with no GL3 inclusions, most likely due to random sectioning.