Table 1. Adhesin topology prediction and additional criteria for the selection of the identified surface exposed proteins as potential targets for the development of drugs, vaccines and/or immunodiagnostic tests.
| Locus Tag1 | Proteinproduct2 | Protein name | Adhesin-liketopology3 | Absence inM. flocculare 4 | Studies suggested a surfacelocalization5 |
| MHP7448_0088 | YP_287488.1 | Hypothetical protein MHP7448_0088 | • | ||
| MHP7448_0138 | YP_287535.1 | Hypothetical protein MHP7448_0138 | • | ||
| MHP7448_0234 | YP_287631.1 | Periplasmic sugar-binding protein | • | • | [46] |
| MHP7448_0309 | YP_287705.1 | NADH-dependent flavin oxidoreductase | • | [48], [49], [50] | |
| MHP7448_0324 | YP_287719.1 | Hypothetical protein MHP7448_0324 | • | ||
| MHP7448_0333 | YP_287728.1 | Hypothetical protein MHP7448_0333 | • | ||
| MHP7448_0352 | YP_287746.1 | Hypothetical protein MHP7448_0352 | • | [29] | |
| MHP7448_0372 | YP_287766.1 | Protein MHP7448_0372 | • | ||
| MHP7448_0373 | YP_287767.1 | Hypothetical protein MHP7448_0373 | • | [30] | |
| MHP7448_0513 | YP_287902.1 | 46 K surface antigen precursor | • | ||
| MHP7448_0629 | YP_288014.1 | Hypothetical protein MHP7448_0629 | • | ||
| MHP7448_0661 | YP_288046.1 | Hypothetical protein MHP7448_0661 | • |
1
Locus tag as defined for M. hyopneumoniae strain 7448 (http://www.ncbi.nlm.nih.gov/genome, NC_007332).
2
Protein product according to NCBI database (http://www.ncbi.nlm.nih.gov).
3
Topology prediction similar to well known adhesins (Table S2).
4
No ortholog found closely related, non-pathogenic species M. flocculare.
5
Published literature.