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. 2014 May 7;136(23):8450–8458. doi: 10.1021/ja503545r

Scheme 5. Synthesis of Peptide Fragments 3: β-hCG[Z38–G71] (A) and 4: β-hCG[Z72–T109] (B).

Scheme 5

Amino acid residues bearing acid-labile protecting groups shown in deep red, pseudoproline dipeptides shown in orange (underlined), Acm-protected Cys residues shown in purple, and thioester functionalities shown in green. Cocktail B: 88% TFA, 5% H2O, 5% phenol (PhOH), 2% triisopropylsilane (TIPSH).