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Effect of DNA geometry on the interplay between the DNA search mechanisms adopted by Pax6 (solid lines), which consists of two tethered DNA binding protein domains (N and C), and its isolated N-domain, Pax6N (dotted lines), at different salt concentrations. (A) Sliding and (B) hopping dynamics are shown on a circular 100 bp DNA molecule (red) and on a linear 100 bp B-DNA molecule (black). Sliding and hopping by the tethered Pax6 are analyzed by focusing solely on its N-domain.
