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. 2014 Oct 28;42(20):12789–12805. doi: 10.1093/nar/gku952

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© The Author(s) 2014. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 7. — Proposed model for the generation and function of vsRNA1. During EV71 infection, a small proportion of viral RNA is processed by Dicer, and vsRNA1 is generated from the IRES (purple). vsRNA1 targets stem-loop II of the viral IRES (marked in green) and downregulates the translation of viral proteins.