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. 2014 Oct 16;42(20):12483–12497. doi: 10.1093/nar/gku953

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© The Author(s) 2014. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 7. — Immunohistochemical staining for S6K2, hnRNPA1 and BCL-XL. TMA samples from lung (n = 204) (A) and breast cancer (n = 194) (B) patients were stained for S6K2, hnRNPA1 and BCL-XL. An increase in S6K2 staining correlates with concomitant increase in BCL-XL and decrease in cytoplasmic hnRNPA1 staining. Patients were grouped (X axis; group 1–4) according to their staining scores for S6K2 and correlation curves between the staining intensities for BCL-XL and cytoplasmic hnRNPA1 with groups 1–4 plotted. Correlation coefficients and P-values (ANOVA test) are shown. (C) Schematic illustration of how FGF-2 signalling regulates the shuttling of hnRNPA1 and the translation of BCL-XL and XIAP mRNAs.