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. 2014 Oct 17;42(20):12806–12821. doi: 10.1093/nar/gku957

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© The Author(s) 2014. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 5. — The Microprocessor cleaves miRNA-like structures embedded in mRNAs. (A–C) Shown are DGCR8-CLIP-enriched RNA fragments mapping to (A) the DGCR8, (B) the AURKB and (C) the BRD2 mRNAs. Reads aligned to the entire loci proclaim specificity of the DGCR8-CLIP experiments. Reads from the DGCR8-CLIP libraries and the Microprocessor-mediated cleavage sites in mRNAs are represented as in Figure 1B. Note that the stem-loop structures and cleavage sites have characteristics of typical pri-miRNAs, whereas the pre-miRNA-like hairpins are uncoupled from miRNA maturation.