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. 2014 Oct 23;42(20):12585–12599. doi: 10.1093/nar/gku965

Figure 5.

Figure 5.

Differentially regulated genes colocalize in a cell cycle-specific manner. Genes that had a ≥2-fold change in transcript level during each cell cycle transition were identified (Supplementary File 5). We then determined whether genes with up- or downregulated transcript levels colocalized at a frequency significantly different from randomly selected genomic regions. A significantly high level of (A) inter- and (B) intrachromosomal colocalization was detected between genes that were upregulated during the G1→G2 transition. (C) Interchromosomal colocalization of downregulated genes occurred at a significantly high level in captured interactions that were shared by M and G1 phases of the cell cycle. (D) Intrachromosomal colocalization of downregulated genes occurred at a significantly high level in the M→G1 and G2→M phase transitions. Venn-diagrams were modified to remove the interaction subsets that were not tested during specific cell cycle phase transitions. Individual P-values are presented in Supplementary Table S12. The expected FDR for (A–D) is 10%.