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Superposition of the three crystal structures of the HDV ribozyme: rebuilt cis-acting C75U-inhibited (PDB ID: 4PRF in gold), rebuilt cleaved (PDB ID: 4PR6 in blue) and trans-acting deoxy-inhibited (PDB ID: 3NKB, ribozyme in green, substrate strand in light green). Active-site metal ions for the two inhibited structures are also shown in corresponding colors. The region surrounding the metal ions forms the active site.
