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X-ray crystal structure (PDB entry 1DQX) of yeast OMPDC in a complex with 6-hydroxyuridine 5′-monophosphate. This structure shows the important interactions of Gln215, Tyr217, and Arg235 side chains from the phosphodianion gripper loop with the ligand phosphodianion. Hydrogen bonds to the Gly234 and Arg235 backbone amides are also shown. Reprinted with permission from ref (28). Copyright 2012 American Chemical Society.
