Table 1. Minimum Inhibitory Concentrations.
| A. MIC (μg/mL) of Axinellamines
for
Gram-Positive and Gram-Negative Bacteria | ||
|---|---|---|
| Strain | Ax A (4) | Ax B (5) |
| E. coli K-12 MG1655 | 4 | 4 |
| Y. pestis KIM6+ | 16 | 32 |
| P. aeruginosa PAO1 | 8 | 8 |
| S. aureus NCTC 8325 | 4 | 4 |
| MRSA N315 | 4 | 4 |
| MRSA USA300 | 2 | 2 |
| S. epidermidis RP62A | 2 | 2 |
| S. pneumoniae D39 | 8 | 8 |
| C. efficiens DSM 44549 | 0.5 | 1 |
| E. faecalis ATCC 33186 | 16 | 8 |
| C. albicans BWP17 | 32 | 32 |
| B. MIC (μg/mL)
of Axinellamines for S. aureus NCTC 8325 as a Function of Added Human Serum | ||||||
|---|---|---|---|---|---|---|
| Serum
(%): |
||||||
| Compd | 0 | 3.1 | 6.3 | 12.5 | 25 | 50 |
| Ax A (4) | 4 | 16 | 16 | 32 | 64 | >64 |
| Ax B (5) | 4 | 16 | 32 | 32 | 64 | >64 |