Skip to main content
. Author manuscript; available in PMC: 2014 Nov 11.
Published in final edited form as: Sci Transl Med. 2013 Mar 20;5(177):177ra37. doi: 10.1126/scitranslmed.3005029

Figure 1.

Figure 1

Chemical structures of compounds used or referred to in this study. Atovaquone and GW8445520 are antimalarial drugs that are known to target the Plasmodium cytochrome bc1 complex. Discovery of endochin as an antimalarial dates back to the 1940’s when it was shown to be effective against several avian plasmodial species but lacked activity against mammalian species. A new structural class of antimalarial agents is represented by ELQ-271, ELQ-300 and P4Q-391, 4(1H)-quinolones bearing a diarylether side chain at the 3-position of the quinolone core. ELQ-300 and P4Q-391 were developed further and tested in a number of rodent models of malaria.